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No, you cannot buy Bactrim or other antibiotics over the counter. Antibiotics are prescription medications that should only be taken under the supervision of a healthcare professional. Can You Get a Bactrim Prescription Online? Generic Bactrim ® Sulfamethoxazole / Trimethoprim Sulfamethoxazole/trimethoprim † is an antibiotic used to treat UTIs. Save on Bactrim Ds (sulfamethoxazole trimethoprim) prescription medication with Blink Pharmacy. Same pills. Lower prices. No coupon req. Sulfamethoxazole-Trimethoprim or Bactrim Savings, Coupons and Information. | SULFAMETHOXAZOLE; TRIMETHOPRIM (suhl fuh meth OK suh zohl; trye METH oh prim) treats infections caused by bacteria. It belongs to a group of medications called sulfonamide antibiotics. For patients Have a question about your prescription? The NextRx online shop and patient accounts are no longer on this site, which is now for clinics and telehealth providers. 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