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Mupirocin is only available as a generic drug; all brands have been discontinued. Generic mupirocin is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. How much does mupirocin (bactroban) cost? $10-$40 without insurance, $3-$12 with insurance. Full cost breakdown, insurance coverage, and how to save. Mupirocin is a naturally occurring antibiotic. It is an antibacterial agent produced by fermentation using the organism Pseudomonas fluorescens. It is active against a wide range of bacteria those responsible for the majority of skin infections, e.g. Staphylococcus aureus including methicillin-resistant Staphylococcus aureus (MRSA) other staphylococci and streptococci. 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