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Quetiapine is used to treat schizophrenia (a mental illness that affects how a person thinks, feels and behaves), bipolar disorder (a disease that causes depression, mania, and other abnormal moods) and major depressive disorder. Quetiapine is in a class of medications called atypical antipsychotics. It works by changing the activity of certain natural substances in the brain. Quetiapine is an atypical antipsychotic used to treat schizophrenia, bipolar disorder, and major depression by balancing brain chemicals linked to mood and behavior. Quetiapine (Seroquel) is an inexpensive drug used to treat schizophrenia and bipolar disorder, also known as manic-depression. This drug is more popular than comparable drugs. It is available in both brand and generic form. Generic quetiapine is is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. Save on Seroquel (quetiapine fumarate) prescription medication with Blink Pharmacy. Same pills. 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