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Management of suspected adverse drug reactions may require temporary interruption and/or dose reduction of NEXAVAR. When dose reduction is necessary, the NEXAVAR dose may be reduced to 400 mg once daily. If additional dose reduction is required, NEXAVAR may be reduced to a single 400 mg dose every other day [see Warnings and Precautions (5)]. Patient Information NEXAVAR® (NEX-A-VAR) (sorafenib) tablets, oral What is NEXAVAR? NEXAVAR is a prescription medicine used to treat: • a type of liver cancer called hepatocellular carcinoma (HCC) that cannot be removed by surgery • a type of kidney cancer called renal cell carcinoma (RCC) • a type of thyroid cancer called differentiated thyroid carcinoma (DTC) that can no longer be … Nexavar (sorafenib) is a targeted anticancer medication that's used for several types of cancers like liver cancer, kidney cancer, and thyroid cancer. Nexavar (sorafenib) is taken by mouth twice a day. 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