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Glucovance ® is a fixed-dose combination therapy containing two anti-hyperglycaemic compounds, metformin hydrochloride and glibenclamide. And is indicated for the treatment of type 2 diabetes in adults, as replacement for previous combination therapy with metformin and glibenclamide in patients whose glycaemia is stable and well-controlled. 1 The advanced tablet technology of Glucovance … The dosage of Glucovance ® should be adjusted depending on renal function parameters (start with 1 tablet of Glucovance ® 500 mg/2.5 mg); regular checks on the renal function are necessary. Patients aged 65 years and older: Starting and maintenance doses of glibenclamide must be carefully adjusted to reduce the risk of hypoglycemia. Glucovance is a fixed-dose combination of metformin and glyburide. It addresses both insulin resistance (via metformin) and insufficient insulin secretion (via glyburide), offering complementary mechanisms in a single tablet. 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